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Rabbit Anti-HHIP/AP Conjugated antibody (bs-12316R-AP)
訂購(gòu)熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-12316R-AP
英文名稱1 Rabbit Anti-HHIP/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的HHIP蛋白抗體
別    名 FLJ20992; FLJ90230; Hedgehog interacting protein; Hedgehog-interacting protein; hedgehoginteracting protein; HHIP; HHIP_HUMAN; HIP.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  干細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 77kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HHIP
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Hedgehog (Hh) signaling proteins are critical for growth and tissue patterning during development. Patched (Ptc), a putative 12 transmembrane receptor, binds to Sonic hedgehog and is suspected to be a negative regulator of Hh signaling. A family member of patched, designated patched 2, has been found to be co-expressed with Sonic hedgehog. Smoothened (Smo), a seven transmembrane receptor, is complexed with patched in many tissues and is believed to be an essential component in the Hh signaling pathway. Hhip (hedgehog-interacting protein) is able to bind to and may be a transcriptional target of all Hh proteins. Binding of Hhip to Hh proteins attenuates hedgehog signaling.

Function:
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.

Subunit:
Interacts with all three hedgehog family members, SHH, IHH and DHH.

Subcellular Location:
Cytoplasm and Cell membrane. Secreted. The last 22 C-terminal amino acids may participate in cell membrane attachment.

Tissue Specificity:
Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney.

Similarity:
Belongs to the HHIP family.
Contains 2 EGF-like domains.

Database links:
UniProtKB/Swiss-Prot: Q96QV1.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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