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Rabbit Anti-SCP3/Gold Conjugated antibody (bs-10660R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@73327.net
訂購QQ:  400-901-9800
技術支持:techsupport@73327.net
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-10660R-Gold
英文名稱1 Rabbit Anti-SCP3/Gold Conjugated antibody
中文名稱 膠體金標記的膽堿磷酸轉移酶1抗體
別    名 SCP3; choline phosphotransferase 1; chpt1; COR 1; COR1; MGC71888; RNASCP3; SCP 3; SCP-3; SPGF4; Sycp 3; Sycp3; SYCP3_HUMAN; Synaptonemal complex protein 3.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  染色質(zhì)和核信號  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SYCP3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]

Function:
Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2.

Subunit:
Interacts with SYCP2.

Subcellular Location:
Nucleus. Chromosome. Note=In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed.

Tissue Specificity:
Testis-specific.

Post-translational modifications:
Phosphorylated.

DISEASE:
Spermatogenic failure 4 (SPGF4) [MIM:270960]: An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the XLR/SYCP3 family.

Database links:

Entrez Gene: 50511 Human

Entrez Gene: 20962 Mouse

Entrez Gene: 25561 Rat

Omim: 604759 Human

SwissProt: Q8IZU3 Human

SwissProt: P70281 Mouse

SwissProt: Q63520 Rat

Unigene: 506504 Human

Unigene: 297977 Mouse

Unigene: 34889 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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