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Rabbit Anti-ABLIM3/Gold Conjugated antibody (bs-12442R-Gold)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@73327.net
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技術(shù)支持:techsupport@73327.net
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-12442R-Gold
英文名稱1 Rabbit Anti-ABLIM3/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的肌動(dòng)蛋白結(jié)合蛋白LIM蛋白3抗體
別    名 abLIM-3; Ablim3; ABLM3_HUMAN; Actin binding LIM protein 3; Actin binding LIM protein family member 3; Actin-binding LIM protein 3; Actin-binding LIM protein family member 3; HMFN1661; KIAA0843.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  結(jié)合蛋白  細(xì)胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 79kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ABLIM3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription.

Function:
May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.

Subunit:
Directly interacts with F-actin and ABRA.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed predominantly in heart and brain.

Similarity:
Contains 1 HP (headpiece) domain.
Contains 4 LIM zinc-binding domains.

Database links:

Entrez Gene: 22885 Human

Entrez Gene: 319713 Mouse

Entrez Gene: 307395 Rat

Omim: 611305 Human

SwissProt: O94929 Human

SwissProt: Q69ZX8 Mouse

Unigene: 49688 Human

Unigene: 329478 Mouse

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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