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Rabbit Anti-HGFA Inhibitor 2/APC Conjugated antibody (bs-10062R-APC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-10062R-APC
英文名稱1 Rabbit Anti-HGFA Inhibitor 2/APC Conjugated antibody
中文名稱 APC標(biāo)記的肝細(xì)胞生長因子激活抑制蛋白2抗體
別    名 Bikunin, placental; DIAR3; HAI-2; HAI2; Hepatocyte growth factor activator inhibitor type 2; Kop; Kunitz type protease inhibitor 2; Kunitz-type protease inhibitor 2; Kunitz-type serine protease inhibitor; PB; Placental bikunin; HGFA Inhibitor2; HGFA Inhibitor-2; Serine peptidase inhibitor Kunitz type 2; Serine protease inhibitor, Kunitz type, 2; SPINT2; SPIT2_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 發(fā)育生物學(xué)  神經(jīng)生物學(xué)  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Guinea Pig, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPINT2/HAI2/HGFA Inhibitor 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Tissue damage, such as hepatic and renal injury, initiates hepatocyte growth factor activator (HGFAC)-mediated limited proteolytic activation of the inactive single-chain precursor form of HGF. Initially, HGFAC is produced as a precursor protein, which is activated by limited proteolysis and is neutralized by specific inhibitors known as HGF activator inhibitors, designated HAIs. HAIs belong to the Kunitz-type serine protease inhibitor family. HAIs target HGF activator and are involved in the regulation of proteolytic activation of HGF in injured tissues. Human HAI-1 transcript is expressed in various human tissues, such as adult placenta, kidney, pancreas, prostate and small intestine, and fetal kidney and lung. It translates into a 478 amino acid protein. The human HAI-2 gene maps to chromosome 19q13.1 and encodes a 252 amino acid protein, also designated human placental bikunin or kop (Kunitz domain containing protein over-expressed in pancreatic cancer). HAI-1 and HAI-2 are produced in membrane-associated forms, which are secreted as active, proteolytically truncated proteins.

Function:
Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.

DISEASE:
Defects in SPINT2 are the cause of diarrhea type 3 (DIAR3) [MIM:270420]; also known as congenital sodium diarrhea (CSD). DIAR3 is a rare, inherited diarrhea of infancy. A diagnosis of DIAR3 is made on the findings of a life-threatening secretory diarrhea, severe metabolic acidosis, and hyponatremia secondary to extraordinarily high fecal losses of sodium, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune, and endocrine causes.

Similarity:
Contains 2 BPTI/Kunitz inhibitor domains.

Database links:

Entrez Gene: 10653 Human

Entrez Gene: 20733 Mouse

Entrez Gene: 292770 Rat

Omim: 605124 Human

SwissProt: O43291 Human

SwissProt: Q9WU03 Mouse

Unigene: 31439 Human

Unigene: 295230 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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