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Rabbit Anti-HAGH/Gold Conjugated antibody (bs-15404R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-15404R-Gold
英文名稱1 Rabbit Anti-HAGH/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的羥酰谷胱甘肽水解酶蛋白抗體
別    名 GLO2; GLX II; Glyoxalase II; HAGH; HAGH1; Hydroxyacyl glutathione hydrolase; Hydroxyacylglutathione hydrolase, mitochondrial; GLO2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  新陳代謝  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Horse, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HAGH
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The glyoxal pathway plays a role in the detoxification of glucose degradation products (GDP). Glyoxalase I and Gyloxalase II (also designated hydroxyacyl glutathione hydrolase or HAGH) are members of the Gyloxalase family. The Gyloxalase II enzyme is a thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form reduced glutathione and D-lactic acid. It exists only as a monomer and binds two zinc ions per subunit. Glyoxalase II contains 260 amino acids. It is detected in the mitochondria and cytosol of mammals. Both Glyoxalase I and Gyloxalase II are detected at a higher activity level in breast cancer tissues than with matched unaffected tissues. This suggests that glyoxalase inhibitor drugs may be effective in the treatment of cancer.

Function:
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

Subunit:
Monomer.

Subcellular Location:
Isoform 1: Mitochondrion matrix.
Isoform 2: Cytoplasm.

Tissue Specificity:
Expressed in liver and kidney.

Similarity:
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Database links:

Entrez Gene: 3029 Human

Entrez Gene: 14651 Mouse

Entrez Gene: 24439 Rat

Omim: 138760 Human

SwissProt: Q16775 Human

SwissProt: Q99KB8 Mouse

SwissProt: O35952 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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