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Rabbit Anti-HEXO/PE-Cy5.5 Conjugated antibody (bs-15470R-PE-Cy5.5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@73327.net
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-15470R-PE-Cy5.5
英文名稱1 Rabbit Anti-HEXO/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的3'-5'外切酶1蛋白抗體
別    名 ERI1; HEXO; THEX1; 3'HEXO; ERI1 exoribonuclease 1; 3' 5' exonuclease ERI 1; 3' 5' exonuclease ERI1; 3' EXO; 3' exoribonuclease; 3' HEXO; 3' histone mRNA exonuclease 1; 3''-5'' exonuclease eri1; 3''-5'' exoribonuclease 1; 3'EXO; 3'HEXO; ERI 1; Eri 1 homolog; Eri-1 homolog; eri1; Eri1 homolog; ERI1_HUMAN; HEXO; Histone mRNA 3' end specific exonuclease; Histone mRNA 3' end specific exoribonuclease; Histone mRNA 3''-end-specific exoribonuclease; Histone mRNA 3''-exonuclease 1; MGC35395; Protein 3''hExo; THEX 1; Three prime histone mRNA exonuclease 1.   
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 染色質(zhì)和核信號(hào)  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 40kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HEXO
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Helicase with RNase motif, more commonly designated Dicer, cleaves double-stranded RNA (dsRNA) in the RNA interference and small temporal RNA (stRNA) pathways, producing active small RNA components (siRNAs) which target the destruction of RNA and repress gene expression. Human Dicer cleaves dsRNA independent of ATP. The 3’-5’ exonuclease ERI-1, also known as Protein 3'hExo, degrades Histone mRNA after replication and may be involved in the regulation of RNA interference. ERI-1 has a high affinity for the stem-loop structure of replication-dependent Histone pre-mRNAs. It requires the 5'-ACCCA-3' sequence present in stem-loop structure. ERI-1 and a stem-loop binding protein (SLBP) target opposite faces of a unique highly conserved stem-loop RNA scaffold towards the 3' end of Histone mRNA.

Function:
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

Subunit:
Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Interacts in a cooperative manner with SLBP to the mature 3'-end of histone mRNAs (By similarity). Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the stem-loop structure of the 3'-end of histone mRNAs.

Subcellular Location:
Cytoplasm. Nucleus. Nucleus, nucleolus.

Similarity:
Contains 1 exonuclease domain.
Contains 1 SAP domain.

Database links:

Entrez Gene: 90459 Human

Entrez Gene: 361159 Rat

Omim: 608739 Human

SwissProt: Q8IV48 Human

SwissProt: Q5FVR4 Rat

Unigene: 20000 Human

Unigene: 17469 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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