| 產(chǎn)品編號(hào) | bs-14494R-BF488 |
| 英文名稱1 | Rabbit Anti-EBNA 3C/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的EB病毒核抗原-3C抗體 |
| 別 名 | EBNA3C; EBNA 4B; EBNA 6; EBNA 3C; EBNA6_EBVB9; EBV; EBV nuclear antigen 6; Epstein Barr nuclear antigen 6; HHV4; Human Herpesvirus 4. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 免疫學(xué) 細(xì)菌及病毒 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 109kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EBNA 3C |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: EBNA 3C is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines and is essential for EBV mediated transformation of these cell lines. This viral nuclear protein is essential for EBV mediated positive immunoblastic lymphomas, and functions as a transcription factor. Function: Plays an essential role for the activation and mmortalization of human B-cells. Represses transcription of viral romoters TP1 and Cp through interaction with host RBPJ, and nhibits EBNA2-mediated activation of these promoters. Since Cp is he promoter for all EBNA mRNAs, EBNA6 probably contributes to a egative autoregulatory control loop. Alternatively, EBNA6 also egulates the transcription of the EBV oncogene LMP1 in a cell ycle-dependent manner. It modulates the activity of several host roteins involved in cell cycle regulation including host cyclin A, YC, RB and p27 mainly through binding to the host SCF(SKP2) omplex. Subunit: Interacts with host CTPB1; this interaction seems mportant for EBNA6-mediated transcriptional repression. Interacts ith host MYC; this interaction enhances MYC stability. Interacts via N-terminus) with host RBPJ. Subcellular Location: Host nucleus matrix. Note=Associated with he nuclear matrix. Similarity: Belongs to the herpesviridae EBNA-6 family. Database links: UniProtKB/Swiss-Prot: P03204.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
