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Rabbit Anti-RCAD/PE-Cy5 Conjugated antibody (bs-17214R-PE-Cy5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-17214R-PE-Cy5
英文名稱1 Rabbit Anti-RCAD/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的RCAD蛋白抗體
別    名 K0776; E3 UFM1-protein ligase 1; KIAA0776; LZAP-binding protein; Maxer; NLBP; RCAD; UFL1; UFL1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 89kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RCAD
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3.

Subcellular Location:
Endoplasmic reticulum. Cytoplasm. In cytoplasm colocalizes with CDK5RAP3.

Tissue Specificity:
Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such HepG2, Hep3B, HLE and PLC.

Post-translational modifications:
Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects each other against ubiquitination and degradation via the proteasome.

Similarity:
Belongs to the UFL1 family.

Database links:

Entrez Gene: 23376 Human

Entrez Gene: 67490 Mouse

Entrez Gene: 313115 Rat

Omim: 613372 Human

SwissProt: O94874 Human

SwissProt: Q8CCJ3 Mouse

SwissProt: B2GV24 Rat

Unigene: 149367 Human

Unigene: 226295 Mouse

Unigene: 12784 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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