| 產(chǎn)品編號 |
bs-17339R-APC |
| 英文名稱1 |
Rabbit Anti-hnRNP A0/APC Conjugated antibody
|
| 中文名稱 |
APC標(biāo)記的異質(zhì)核糖核蛋白A0抗體 |
| 別 名 |
HNRNPA0;
Heterogeneous nuclear ribonucleoprotein A0;
hnRNA binding protein;
hnRNP A0;
HNRNPA0;
ROA0_HUMAN. |
| 規(guī)格價(jià)格 |
100ul/2980元
購買 大包裝/詢價(jià) |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
細(xì)胞生物 結(jié)合蛋白 表觀遺傳學(xué) |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Mouse,
(predicted: Human, Rat, Dog, Pig, Cow, Rabbit, Sheep, Cynomolgus Monkey, Rhesus monkey, Gorilla, Marmoset (common))
|
| 產(chǎn)品應(yīng)用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
31kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human hnRNP A0 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to mRNA transcription and pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. There are approximately 20 known hnRNP proteins and their complexes are the major constituents of the spliceosome. The majority of hnRNP protein components are localized to the nucleus; however, some shuttle between the nucleus and the cytoplasm. hnRNP I, also designated polypyrimidine tract-binding protein (PTB), and its homolog hnRNP L, bind to the 3' end of introns to modulate alternative splicing mechanisms of pre-mRNAs in normal cells and the translation of sev-eral viruses, including hepatitis C virus (HCV). The human hnRNP I gene maps to chromosome 19p13.3 and encodes a protein that is localized in the nucleoplasm. hnRNP L, like hnRNP I, is also localized in the nucleoplasm.
Function:
This protein is a component of ribonucleosomes.
Subcellular Location:
Nucleus. Component of ribonucleosomes.
Post-translational modifications:
Arg-291 is dimethylated, probably to asymmetric dimethylarginine.
Similarity:
Contains 2 RRM (RNA recognition motif) domains.
Database links:
Entrez Gene: 416302 Chicken
Entrez Gene: 745876 Chimpanzee
Entrez Gene: 540311 Cow
Entrez Gene: 481524 Dog
Entrez Gene: 10949 Human
Entrez Gene: 77134 Mouse
Entrez Gene: 498696 Rat
Omim: 609409 Human
SwissProt: Q13151 Human
SwissProt: Q9CX86 Mouse
Unigene: 645902 Human
Unigene: 96996 Human
Unigene: 490274 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
|
