| 產(chǎn)品編號(hào) |
bs-17356R-PE |
| 英文名稱1 |
Rabbit Anti-HOPX/PE Conjugated antibody
|
| 中文名稱 |
PE標(biāo)記的絨毛膜癌不表達(dá)蛋白1抗體 |
| 別 名 |
CAMEO;
heart odd homeobox 1 protein;
HOD;
Homeodomain-only protein;
HOP;
HOP homeobox;
HOP_HUMAN;
HOPX;
LAGY;
Lung cancer-associated Y protein;
NECC1;
Not expressed in choriocarcinoma clone 1;
Not expressed in choriocarcinoma protein 1;
OB1;
odd homeobox 1 protein;
Odd homeobox protein 1;
OTTHUMP00000158970;
SMAP31;
TOTO. |
| 規(guī)格價(jià)格 |
100ul/2980元
購買 大包裝/詢價(jià) |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
心血管 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Rat,
(predicted: Human, Mouse, Pig, Cow, Horse, )
|
| 產(chǎn)品應(yīng)用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
8kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human HOPX |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]
Function:
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma.
Similarity:
Contains 1 homeobox DNA-binding domain.
Database links:
Entrez Gene: 281270 Cow
Entrez Gene: 84525 Human
Entrez Gene: 74318 Mouse
Entrez Gene: 396692 Pig
Entrez Gene: 171160 Rat
Omim: 607275 Human
SwissProt: Q8MJD5 Cow
SwissProt: Q9BPY8 Human
SwissProt: Q8R1H0 Mouse
SwissProt: Q8MJD6 Pig
SwissProt: Q78ZR5 Rat
Unigene: 619396 Human
Unigene: 181852 Mouse
Unigene: 478741 Mouse
Unigene: 2989 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
|
