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Rabbit Anti-Orai1/Gold Conjugated antibody (bs-18019R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@73327.net
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-18019R-Gold
英文名稱1 Rabbit Anti-Orai1/Gold Conjugated antibody
中文名稱 膠體金標記的嗅覺受體ai1抗體
別    名 Calcium release activated calcium channel protein 1; Calcium release activated calcium modulator 1; Calcium release-activated calcium channel protein 1; CRACM 1; CRACM1; CRCM1; CRCM1_HUMAN; FLJ14466; Orai 1; ORAI calcium release activated calcium modulator 1; orai1; ORAT1; Protein orai 1; Protein orai-1; TMEM 142A; TMEM142A; Transmembrane protein 142A.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細胞生物  神經(jīng)生物學  信號轉(zhuǎn)導  細胞膜受體  G蛋白偶聯(lián)受體  t-淋巴細胞  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Orai1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Calcium release activated calcium channel protein 1; Calcium release activated calcium modulator 1; Calcium release-activated calcium channel protein 1; CRACM 1; CRACM1; CRCM1; CRCM1_HUMAN; FLJ14466; Orai 1; ORAI calcium release activated calcium modulator 1; orai1; ORAT1; Protein orai 1; Protein orai-1; TMEM 142A; TMEM142A; Transmembrane protein 142A.

Function:
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.

Subcellular Location:
Cell membrane.

DISEASE:
Defects in ORAI1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1) [MIM:612782]. IDTICED1 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, and normal lymphocytes counts and serum immunoglobulin levels. In surviving patients ectodermal dysplasia with anhydrosis and non-progressive myopathy may be observed.

Similarity:
Belongs to the Orai family.

Database links:

Entrez Gene: 84876 Human

Entrez Gene: 517688 Cow

Entrez Gene: 109305 Mouse

Entrez Gene: 100154923 Pig

Entrez Gene: 304496 Rat

Omim: 610277 Human

SwissProt: Q96D31 Human

SwissProt: Q8BWG9 Mouse

SwissProt: Q5M848 Rat

Unigene: 55148 Human

Unigene: 218582 Mouse

Unigene: 3869 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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