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Rabbit Anti-LMOD2/BF594 Conjugated antibody (bs-18316R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-18316R-BF594
英文名稱1 Rabbit Anti-LMOD2/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的平滑肌蛋白LMOD2抗體
別    名 C-LMOD; Cardiac leiomodin; Leiomodin 2 (cardiac); Leiomodin-2; LMOD2; LMOD2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 心血管  細(xì)胞生物  發(fā)育生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LMOD2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Members of the Leiomodin protein family are closely related to the tropomodulin family of actin filament pointed end-capping proteins. Leiomodins are actin-binding proteins that act as strong filament nucleators in muscle cells. Leiomodin 1 is highly expressed in a variety of tissues that contain smooth muscle, therefore it is also known as smooth muscle Leiomodin, or SM-Lmod. Also designated C-Lmod, Leiomodin 3 is found in several types of fetal tissue and is involved in tropomyosin binding. Leiomodin 2, also known as C-LMOD or LMOD2, is a 547 amino acid protein that is specifically expressed in heart and skeletal muscles. Leiomodin 2 binds to tropomyosin and may block the elongation and depolymerization of actin filaments at their pointed end. Leiomodin 2 is encoded by a gene that is located near the hypertrophic cardiomyopathy locus CMH6 on chromosome 7, suggesting that Leiomodin 2 may be involved in that disease process. Leiomodin 2 is expressed as three alternatively spliced variants.

Function:
May block the elongation and depolymerization of the actin filaments at the pointed end.

Tissue Specificity:
Specifically expressed in heart and skeletal muscles. Not expressed in other tissues.

Similarity:
Belongs to the tropomodulin family.
Contains 1 WH2 domain.

Database links:

Entrez Gene: 442721 Human

Entrez Gene: 93677 Mouse

Omim: 608006 Human

SwissProt: Q6P5Q4 Human

SwissProt: Q3UHZ5 Mouse

Unigene: 592260 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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