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Rabbit Anti-PTPN12/PE Conjugated antibody (bs-19589R-PE)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-19589R-PE
英文名稱1 Rabbit Anti-PTPN12/PE Conjugated antibody
中文名稱 PE標(biāo)記的酪氨酸蛋白磷酸酶非受體型12抗體
別    名 Protein tyrosine phosphatase G1; Protein tyrosine phosphatase non receptor type 12; Protein-tyrosine phosphatase G1; PTN12_HUMAN; PTP PEST; PTP-PEST; PTPG1; Ptpn12; Tyrosine protein phosphatase non receptor type 12; Tyrosine-protein phosphatase non-receptor type 12.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  激酶和磷酸酶  細(xì)胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 88kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTPN12
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Function:
Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.

Subunit:
Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN (By similarity). {ECO:0000250}.

Subcellular Location:
Cytoplasm.

Post-translational modifications:
Phosphorylated by STK24/MST3 and this results in inhibition of its activity. {ECO:0000269|PubMed:17046825}.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Contains 1 tyrosine-protein phosphatase domain.

Database links:

Entrez Gene: 5782 Human

Entrez Gene: 531877 Cow

Entrez Gene: 19248 Mouse

Entrez Gene: 117255 Rat

Omim: 600079 Human

SwissProt: Q05209 Human

SwissProt: P35831 Mouse

SwissProt: Q63745 Rat

Unigene: 34723 Cow

Unigene: 61812 Human

Unigene: 319117 Mouse

Unigene: 10707 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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