来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
色狠狠久久AV五月综合|精品久久一级二级三级
Rabbit Anti-PUF60/BF350 Conjugated antibody (bs-19595R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@73327.net
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-19595R-BF350
英文名稱1 Rabbit Anti-PUF60/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的SIAH結(jié)合蛋白1抗體
別    名 60 kDa poly(U)-binding-splicing factor; FBP-interacting repressor; FIR; FLJ31379; FUSE-binding protein-interacting repressor; Poly U binding splicing factor 60KDa; Poly(U)-binding-splicing factor PUF60; poly-U binding splicing factor PUF60; PUF60; PUF60_HUMAN; pyrimidine tract binding splicing factor; Ro ribonucleoprotein-binding protein 1; Ro-binding protein 1; RoBP1; RoBPI; siah binding protein 1; Siah-binding protein 1; Siah-BP1; SIAHBP1.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  轉(zhuǎn)錄調(diào)節(jié)因子  結(jié)合蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PUF60
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Function:
DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.

Subcellular Location:
Nucleus. Colocalizes partially with TROVE2.

Tissue Specificity:
Isoform 2 is expressed in colonic epithelium and colorectal epithelium cancer (at protein level). Isoform 6 is expressed in colorectal epithelial cancer but below detection level in colonic epithelium. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.

Similarity:
Belongs to the RRM half pint family.
Contains 3 RRM (RNA recognition motif) domains.

Database links:

Entrez Gene: 22827 Human

Entrez Gene: 67959 Mouse

Entrez Gene: 84401 Rat

Omim: 604819 Human

SwissProt: Q9UHX1 Human

SwissProt: Q3UEB3 Mouse

SwissProt: Q9WV25 Rat

Unigene: 521924 Human

Unigene: 29965 Mouse

Unigene: 96174 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.73327.net 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
JIZZ日本| 午夜精品久久久久久久无码 | 人妻中文字幕精品一区二区| 97亚洲狠狠色综合久久久久| 亚洲精品一区中文字幕乱码| 亚洲日本精品一区二区三区| 亚洲精品久久无码| 黑人狂躁日本妞无码| 免费观看黃色A片观看| 欧美巨大XXXX做受| 精品国内自产拍在线| 大白肥妇BBVBBW高潮| 国产精品99久久久久久人小| 国产a级久久久精品| 亚洲高清中文字幕专区| 亚洲美女高潮久久久久久久久| 久久亚洲AV无码精品色午夜麻豆 | 无码免费一区二区三区免费播放| 国产欧美一区二区精品忘忧草| 老子午夜精品无码| 亚洲 小说 欧美 激情 另类| 欧美三级久久久久久| 18禁男女爽爽爽午夜网站免费| 国产精品偷伦视频免费观看了| 好涨嗯太深了嗯啊用力别停| 日韩欧美国产中文字幕制服| 18禁真人抽搐一进一出免费| 久久精品视频在线观看6| 亚洲a∨一区二区三区性色| 精品一区二区久久久久久| 亚洲AV综合色区无码| 人妻人妻与人妻人妻AV| 老BWBWBWBWBWBWBW| 精品国产三级av在线一百度| 亚洲国产成人精品日韩18 | 亚VA芒果乱码一二三四区别| 久久99热成人精品国产| 荫蒂每天被三个男人添小说| 歪歪漫画网站页面入口弹窗秋蝉| 国产乱XXXXX97国语对白| 人妻人人澡人人添人人爽|