| 產(chǎn)品編號 |
bsm-10895M-PE-Cy3 |
| 英文名稱1 |
Mouse Anti-TIMP-1/PE-Cy3 Conjugated antibody
|
| 中文名稱 |
PE-Cy3標(biāo)記的鼠抗金屬蛋白酶組織抑制因子-1單克隆抗體 |
| 別 名 |
Clgi; Collagenase inhibitor; EPA; EPO; Erythroid Potentiating Activity; Fibroblast collagenase inhibitor; FLJ90373; HC; Human Collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; OTTHUMP00000023214; TIMP 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP1 protein; Tissue Inhibitor of Metalloproteinase 1; Tissue inhibitor of metalloproteinases; Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor. |
| 規(guī)格價格 |
100ul/2980元
購買 大包裝/詢價 |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 細(xì)胞凋亡 生長因子和激素 激酶和磷酸酶 合成與降解 |
| 抗體來源 |
Mouse |
| 克隆類型 |
Monoclonal |
| 交叉反應(yīng) |
Human, Mouse, Rat,
|
| 產(chǎn)品應(yīng)用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
21kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
Recombinant human TIMP-1 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein G |
| 儲 存 液 |
Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq].
Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
Subcellular Location:
Secreted.
Post-translational modifications:
The activity of TIMP1 is dependent on the presence of disulfide bonds.
Similarity:
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.
Database links:
Entrez Gene: 7076 Human
Entrez Gene: 21857 Mouse
Omim: 305370 Human
SwissProt: P01033 Human
SwissProt: P12032 Mouse
Unigene: 522632 Human
Unigene: 8245 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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