| 產(chǎn)品編號 | bsm-51207M-Gold |
| 英文名稱1 | Mouse Anti-LOX/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的小鼠抗蛋白賴氨酸-6-氧化酶單克隆抗體 |
| 別 名 | lox; LYOX; LYOX_HUMAN; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號 | 4C3 |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Pig, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LOX |
| 亞 型 | IgG2b |
| 純化方法 | affinity purified by Protein G |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Subcellular Location: Secreted; extracellular space Tissue Specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas. Post-translational modifications: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytically activated by BMP1 (By similarity). Similarity: Belongs to the lysyl oxidase family. Database links: Entrez Gene: 396474 Chicken Entrez Gene: 4015 Human Entrez Gene: 16948 Mouse Omim: 153455 Human SwissProt: Q05063 Chicken SwissProt: P28300 Human SwissProt: P28301 Mouse Unigene: 102267 Human Unigene: 172 Mouse Unigene: 11372 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
