来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關于我們  聯(lián)系我們
禁止18点击进入在线看片尤物|学生黄区免费视频观看
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-IL-4R/BF555 Conjugated antibody (bs-23578R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@73327.net
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-23578R-BF555
英文名稱1 Rabbit Anti-IL-4R/BF555 Conjugated antibody
中文名稱 BF555標記的白細胞介素4受體抗體
別    名 Interleukin-4 Receptor; 582J2.1; CD124; CD-124; CD 124; IL 4R alpha; IL4RA; Interleukin 4 receptor alpha chain; MGC118473.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  細胞膜受體  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, 
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 88kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-4R
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.

Subunit:
The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP. Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Tissue Specificity:
Isoform 1 and isoform 2 are highly expressed in activated T-cells.

Post-translational modifications:
On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.
The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.

Similarity:
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Contains 1 fibronectin type-III domain.

Database links:

Entrez Gene: 3566 Human

Entrez Gene: 16190 Mouse

Entrez Gene: 25084 Rat

Omim: 147781 Human

SwissProt: P24394 Human

SwissProt: P16382 Mouse

SwissProt: Q63257 Rat

Unigene: 513457 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.73327.net 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
亚洲AV无码国产精品色午友在线| 国产乱子伦视频大全亚琴影院| 女厕偷窥一区二区三区| 日韩精品中文字幕有码专区| 欧美精品一区二区少妇免费A片| 日本在线一区二区三区直播| 豆国产97在线 | 亚洲| 成人免费毛片aaaaaa片| 精品日韩人妻一区二区三区| 亚洲欧美国产日韩精品妖精| 亚洲AV成人无码久久精品| 性XXXX18精品A片一区二区| 在线亚洲制服视频| 亚洲人av成一区二区电影| 亚洲a∨一区二区三区性色| 欧美乱大交XXXXX| 国产美女精品一区二区三区| 鲁一鲁一鲁一鲁一澡| 成人免费无遮挡无码黄漫视频| 日本精品一区二区三区免费| 少妇BBW搡BBBB搡BBBB| 亚洲精品久久久口爆吞精| 人妻无码二区自慰系列| 在熟睡夫面前侵犯我在线播放| 九九色情网依依网| 欧美丰满熟妇BBBBBB百度| 樱桃视频大全免费高清版| 国产精品毛片拍拍拍| 亚洲精品久久久久69影院| 亚洲熟妇无码一区二区三区导航| 精品夜夜爽欧美毛片视频| 日韩精品一二三区在线播放| (无码视频)在线观看| 国产,日韩,丝袜,欧美一区| 78午夜福利视频| YIN荡护士揉捏乱P办公室视频| 亚洲一二三四区欧美激情| 亚洲AV无码男人的天堂| 日本午夜电影一区二区| 欧美激情伦理片一区二区| 国产精品尤物在线免费观看|